Identification of the E3 ligase TRIM21 as a crucial regulator of STAT1 in metabolic dysfunction—associated steatohepatitis
The ubiquitination of STAT1 in MASH is regulated by TRIM21 which is a key suppressor of MASH. TRIM21 acts as a negative regulator in hepatic steatosis and offers potential therapeutic opportunities for MASH.
Authors
- Zhen Huang (ORCID: https://orcid.org/0000-0002-0498-1462)
- Xun-xun Chen
- Hui-Ting Shi
- Leiming Wu (ORCID: https://orcid.org/0000-0002-2549-6458)
- Lina Wu
- Lili Xiao
- Bin-Bin Du
- Dian-Hong Zhang
- Huan Li
- Jie-Lei Zhang
Institutions
- First Affiliated Hospital of Zhengzhou University (CN)
Publication Details
- Journal
- Cell Communication and Signaling
- Published
- 2026-01-21
- DOI
- https://doi.org/10.1186/s12964-026-02668-8
- Primary Topic
- Cytokine Signaling Pathways and Interactions
- Type
- article
- Field-Weighted Citation Impact
- 0.00