Sex Differences in Left Ventricular Remodeling for Risk Stratification of Patients With Aortic Regurgitation
In this study among individuals with moderate-severe AR, similar LVESDi thresholds (20 mm/m2) for both sexes, but lower than currently recommended by guidelines, were independently associated with mortality. In turn, LVESVi thresholds were 40 mL/m2 for women and 45 mL/m2 for men, suggesting the need for sex-specific cutoffs to improve risk stratification.
Authors
- Maria Chiara Meucci (ORCID: https://orcid.org/0000-0001-5474-0555)
- Camille Sarrazyn (ORCID: https://orcid.org/0000-0002-5382-5140)
- Alice Bergeron
- A P A Chua
- Edgar Tay
- Philippe Pibarot
- Nina Ajmone Marsan
- Roxana Enache
- Federico Fortuni
- Jérémy Bernard
- Jingnan Zhang
- Pilar Lopez Santi
- Steele C. Butcher
- Kai-Hang Yiu
- Jeroen J. Bax
Institutions
- Ecolab (United Kingdom) (GB)
- Carol Davila University of Medicine and Pharmacy (RO)
- Royal Perth Hospital (AU)
- Leiden University Medical Center (NL)
- Queen Mary Hospital (CN)
- Agostino Gemelli University Polyclinic (IT)
- Azienda Ospedaliero Universitaria San Giovanni Battista (IT)
- National University Heart Centre Singapore (SG)
- Institut universitaire de cardiologie et de pneumologie de Québec (CA)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- University of Hong Kong (HK)
Publication Details
- Journal
- JAMA Cardiology
- Published
- 2026-01-21
- DOI
- https://doi.org/10.1001/jamacardio.2025.5249
- Citations
- 1
- Primary Topic
- Cardiac Valve Diseases and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 30.07