Comparison of 3 Forms of Clinically Available Hydroxyapatite Artificial Bone for Use in Biphasic Implants With Synovial Mesenchymal Stem Cell–Derived Tissue-Engineered Constructs for Osteochondral Repair
This study highlights the potential of biphasic implants combining clinically available TEC and HA artificial bone for osteochondral repair. The biphasic implant can be easily prepared intraoperatively without specialized fabrication. Long-term observations revealed distinct repair patterns for each HA form, which may assist surgeons in selecting the optimal HA artificial bone form for effective and durable subchondral bone repair in osteochondral regeneration.
Authors
- George Jacob (ORCID: https://orcid.org/0000-0003-0744-1469)
- Seiji Okada (ORCID: https://orcid.org/0000-0002-5107-8209)
- Hiromichi Fujie (ORCID: https://orcid.org/0000-0003-2924-9945)
- M. NAKAMURA
- Kazunori Shimomura (ORCID: https://orcid.org/0000-0001-8931-146X)
- Wataru Andō (ORCID: https://orcid.org/0000-0002-9352-465X)
- Taro Akimori
- Seido Yarimitsu
- David A. Hart
- Norimasa Nakamura
Institutions
- Kyushu University (JP)
- University of Calgary (CA)
- Kansai University of Welfare Sciences (JP)
- Cochin University of Science and Technology (IN)
- Lakeshore Hospital (IN)
- Osaka Health Science University (JP)
- Kansai Rosai Hospital (JP)
- Alberta Bone and Joint Health Institute (CA)
- Tokyo Metropolitan University (JP)
- The University of Osaka (JP)
Publication Details
- Journal
- The American Journal of Sports Medicine
- Published
- 2026-01-21
- DOI
- https://doi.org/10.1177/03635465251407260
- Primary Topic
- Osteoarthritis Treatment and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00