<i>TET2</i> and <i>TP53</i> Mutations Cooperatively Modulate the Response to Inflammation to Promote Leukemic Transformation
<i>TET2</i> and <i>TP53</i> mutations co-operate leading to advanced hematologic malignancy. <i>TET2</i> mutations promote an inflammatory environment and <i>TP53</i> mutation supports tolerance to this inflammatory stress.
Authors
- Sebastian El Ghaity-Beckley (ORCID: https://orcid.org/0000-0001-5878-0597)
- Jacob Glass
- Isabelle Csete (ORCID: https://orcid.org/0000-0002-1750-8404)
- R. L. Levine
- Jonathan Foox
- Pablo Sanchez Vela
- Matthew G. Wereski
- Claudi Brady
- Alan H Shih
- Bridget K Marcellino
- Richard P Koche
- Brianna Kelly
Institutions
- Memorial Sloan Kettering Cancer Center (US)
- Prince Sattam Bin Abdulaziz University (SA)
- Cornell University (US)
- Kettering University (US)
- Tisch Hospital (US)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- bioRxiv (Cold Spring Harbor Laboratory)
- Published
- 2026-01-20
- DOI
- https://doi.org/10.64898/2026.01.20.700390
- Primary Topic
- Acute Myeloid Leukemia Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Gilead Sciences
- Cycle for Survival
- Weill Cornell Medical College
- Marie-Josée and Henry R. Kravis Center for Molecular Oncology
- National Cancer Institute