Gastroenteropancreatic neuroendocrine neoplasms in children and adults: a comparative review
Although histological frameworks are shared, pediatric GEPNENs differ from adult disease in genetics, site distribution, functional status, and survivorship challenges. Adult evidence may be cautiously adapted to pediatrics, but pediatric-specific guidelines and collaborative research are urgently needed to address unique biological and clinical features and to harmonize long-term care.
Authors
- Antje Redlich (ORCID: https://orcid.org/0000-0002-1732-1869)
- Marianne Pavel (ORCID: https://orcid.org/0000-0002-9669-5294)
- Rainer Claus (ORCID: https://orcid.org/0000-0003-2617-8766)
- Michaela Kuhlen
- Nehara Begum
Institutions
- University of Augsburg (DE)
- European Neuroendocrine Tumor Society (DE)
- Cancer Research Center (US)
- Centro de Investigación del Cáncer (ES)
- Comprehensive Cancer Center Erlangen (DE)
- Otto-von-Guericke-Universität Magdeburg (DE)
Publication Details
- Journal
- Frontiers in Endocrinology
- Published
- 2026-01-21
- DOI
- https://doi.org/10.3389/fendo.2025.1736543
- Citations
- 1
- Primary Topic
- Neuroendocrine Tumor Research Advances
- Type
- article
- Field-Weighted Citation Impact
- 31.52
Funders
- Deutsche Kinderkrebsstiftung