Multi-omics integrative analysis of stemness-associated pathological signatures to guide prognosis and therapeutic strategies in uveal melanoma

This study highlights a novel integrative framework combining pathomics and scRNA-seq to decode stemness-driven heterogeneity in UVM. The IPS model offers a non-invasive tool for risk stratification and therapeutic guidance, paving the way for precision oncology in rare ocular malignancies. Notably, the IPS was derived and internally validated within a single TCGA-UVM cohort, and its generalizability to other populations requires validation in independent multi-center cohorts.