Case Report: Mammary Paget’s disease with multifocal microinvasive carcinoma and extensive lymph node metastasis: therapeutic challenges and insights from a case of stage pT1mic pN3c cM0

Although no definite mass was identified on breast magnetic resonance imaging (MRI) in this case, SLNB and subsequent pathology confirmed extensive lymph node metastasis (pN3c). Omission of SLNB could have led to understaging and compromised treatment decision-making. This single case may suggest that SLNB holds significant staging value for MPD patients with no obvious breast mass on imaging. It provides hypothesis-generating, practical evidence for addressing this controversial clinical issue, warranting further investigation in larger cohorts.

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Publication Details

Journal
Frontiers in Oncology
Published
2026-01-21
DOI
https://doi.org/10.3389/fonc.2025.1727016
Primary Topic
Cancer and Skin Lesions
Type
article
Field-Weighted Citation Impact
0.00
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article

Case Report: Mammary Paget’s disease with multifocal microinvasive carcinoma and extensive lymph node metastasis: therapeutic challenges and insights from a case of stage pT1mic pN3c cM0

Jing Luo, ZhiYu Liu, YiFan Luo
Frontiers in Oncology
Cancer and Skin Lesions
article

Case Report: Mammary Paget’s disease with multifocal microinvasive carcinoma and extensive lymph node metastasis: therapeutic challenges and insights from a case of stage pT1mic pN3c cM0

Jing Luo, ZhiYu Liu, YiFan Luo
article en

Abstract

Although no definite mass was identified on breast magnetic resonance imaging (MRI) in this case, SLNB and subsequent pathology confirmed extensive lymph node metastasis (pN3c). Omission of SLNB could have led to understaging and compromised treatment decision-making. This single case may suggest that SLNB holds significant staging value for MPD patients with no obvious breast mass on imaging. It provides hypothesis-generating, practical evidence for addressing this controversial clinical issue, warranting further investigation in larger cohorts.

Frontiers in OncologyVol. 15
Affiliated Hospital of Southwest Medical University (CN), Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital (CN)
Peace, Justice and strong institutions
Openalex Percentile: Top 83%
Cancer and Skin Lesions
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