Transcriptional response to combination antiretroviral therapy predicts side effects and novel targets
ART regimens affected transcriptional signatures of genes involved in HIV-host PPIs and were less tied to common ART-related side effects. Our findings support the use of high-throughput transcriptomics to detect specific mechanisms of ART on- and off-target effects to help prioritize new drug targets and compounds in future development and optimization of safer and more efficient ART.
Authors
- Alexander Lachmann (ORCID: https://orcid.org/0000-0002-1982-7652)
- Letizia Amadori (ORCID: https://orcid.org/0000-0003-1125-4631)
- Chiara Giannarelli (ORCID: https://orcid.org/0000-0003-2473-6058)
- Ma’ayan Avi
- Paola Nicoletti
- Inga Peter
- Heidi M. Crane
Institutions
- University of Washington (US)
- NYU Langone Health (US)
- New York University (US)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2026-01-21
- DOI
- https://doi.org/10.3389/fphar.2025.1743543
- Primary Topic
- HIV/AIDS drug development and treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Georgia Clinical and Translational Science Alliance
- National Institutes of Health
- National Center for Advancing Translational Sciences