Microgravity-induced transcriptional reprogramming in embryonic chicken limb bud-derived chondrogenic cultures
These findings demonstrate that simulated microgravity rapidly induces reversible molecular and cellular adaptations related to cartilage homeostasis and mechanotransduction in this chondrogenic model system. The RPM platform offers a powerful tool to dissect chondrogenesis, cartilage biology, and lineage plasticity under mechanical unloading, providing insights with broad relevance to skeletal tissue mechanobiology.
Authors
- Péter Szentesi (ORCID: https://orcid.org/0000-0003-2621-2282)
- Tibor Hajdú (ORCID: https://orcid.org/0000-0002-9954-1987)
- Krisztián Z. Juhász
- Zhangzheng Wang (ORCID: https://orcid.org/0000-0003-3871-5143)
- Róza Zákány (ORCID: https://orcid.org/0000-0003-1059-0422)
- Patrik Kovács (ORCID: https://orcid.org/0000-0003-1588-7962)
- Roland Takács (ORCID: https://orcid.org/0000-0002-1598-3922)
- Szilárd Póliska (ORCID: https://orcid.org/0000-0002-9722-251X)
- Éva Katona (ORCID: https://orcid.org/0000-0002-8166-1438)
- László Csernoch (ORCID: https://orcid.org/0000-0002-2446-1456)
- Csaba Matta (ORCID: https://orcid.org/0000-0002-9678-7420)
- Judit Vágó
Institutions
- University of Debrecen (HU)
Publication Details
- Journal
- Frontiers in Cell and Developmental Biology
- Published
- 2026-01-21
- DOI
- https://doi.org/10.3389/fcell.2026.1746313
- Primary Topic
- Spaceflight effects on biology
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Debreceni Egyetem