Effect of High-Dose Oral Insulin in Children With Stage 1 Type 1 Diabetes: The Fr1da Insulin Intervention Randomized Controlled Trial
In children with stage 1 T1D, 1 year of high-dose oral insulin did not alter progression to dysglycemia or diabetes or immune response to insulin.
Authors
- Robin Assfalg (ORCID: https://orcid.org/0000-0003-1277-716X)
- Anna Hofelich
- Isabelle Serr (ORCID: https://orcid.org/0000-0001-9277-9055)
- Stefanie Arnolds
- Claudia Matzke
- Jan Knoop
- Kerstin Kick (ORCID: https://orcid.org/0000-0002-9139-1339)
- Carolin Daniel (ORCID: https://orcid.org/0000-0003-4698-7069)
- Andreas Weiß (ORCID: https://orcid.org/0000-0001-9597-0576)
- Marc Weigelt
- Anette-Gabriele Ziegler
- Markus Pfirrmann
- Melanie Bunk
- Ali Albeer
- Mirjam Kohls
- Peter Achenbach
- Stefanie Jacobsen
- Christiane Winkler
- Katharina Schütte-Borkovec
- Marlon Scholz
Institutions
- Zimmer Biomet (Netherlands) (NL)
- Helmholtz Zentrum München (DE)
- Kinderkrankenhaus auf der Bult (DE)
- Deutsches Diabetes-Zentrum e.V. (DE)
- German Center for Diabetes Research (DE)
- Paul Langerhans Institute Dresden (DE)
- Hochschule für Technik und Wirtschaft Dresden – University of Applied Sciences (DE)
- Heinrich Heine University Düsseldorf (DE)
- Technical University of Munich (DE)
- Technische Universität Dresden (DE)
- Ludwig-Maximilians-Universität München (DE)
Publication Details
- Journal
- Diabetes Care
- Published
- 2026-01-21
- DOI
- https://doi.org/10.2337/dc25-2818
- Primary Topic
- Diabetes Management and Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Eli Lilly and Company
- Sanofi
- Leona M. and Harry B. Helmsley Charitable Trust
- Lunds Universitet