Demethylation of leptin promoter in gestational diabetes mellitus: evidence from a mouse model
Decidual LEP promoter demethylation is associated with hyperleptinemia and shows an epigenetic mechanism linking GDM. LEP promoter demethylation may reflect the metabolic disturbance in GDM and serve as a potential early marker for GDM.
Authors
- Xin Zheng (ORCID: https://orcid.org/0000-0002-5506-8112)
- Jianguang Ji
- Huan Yi
- Linlin Hu
- Hang Lin
- Xiaojing Huang
- Lin Tu
- Shupei Zhang
- Shihuang Liu
Institutions
- Fujian Medical University (CN)
- University of Macau (MO)
- Fujian Women and Children Hospital (CN)
- Guangxi Maternal and Child Health Hospital (CN)
- Fuzhou Maternity and Child Health Care Hospital (CN)
- Maternal and Child Health Care Hospital of Bao'an (CN)
- Second Affiliated Hospital of Fujian Medical University (CN)
Publication Details
- Journal
- Frontiers in Cell and Developmental Biology
- Published
- 2026-01-21
- DOI
- https://doi.org/10.3389/fcell.2026.1729477
- Primary Topic
- Gestational Diabetes Research and Management
- Type
- article
- Field-Weighted Citation Impact
- 0.00