Persistent Seronegativity and Absence of Intact Proviruses Despite Prolonged Initial Viremia in Early-Treated Perinatal HIV Infection

We report an adolescent with perinatal HIV-1 infection treated from 1 month of age. Despite persistent viremia until age 4, he exhibited negative or weakly reactive serologies and no detectable intact proviruses at 11 and 18 years. This case questions current definitions of seroconversion, HIV persistence and remission in children.

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Publication Details

Journal
Open Forum Infectious Diseases
Published
2025-12-26
DOI
https://doi.org/10.1093/ofid/ofaf815
Primary Topic
HIV Research and Treatment
Type
article
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article

Persistent Seronegativity and Absence of Intact Proviruses Despite Prolonged Initial Viremia in Early-Treated Perinatal HIV Infection

Florence Buseyne, S. Blanche, Caroline Charre, Alice-Andrée Mariaggi et al.
Open Forum Infectious Diseases
HIV Research and Treatment
article

Persistent Seronegativity and Absence of Intact Proviruses Despite Prolonged Initial Viremia in Early-Treated Perinatal HIV Infection

Florence Buseyne, S. Blanche, Caroline Charre, Alice-Andrée Mariaggi, Pierre Frange, Jérôme Le Chenadec, Josiane Warszawski, Adeline Mélard, Thomas Montange
article en

Abstract

We report an adolescent with perinatal HIV-1 infection treated from 1 month of age. Despite persistent viremia until age 4, he exhibited negative or weakly reactive serologies and no detectable intact proviruses at 11 and 18 years. This case questions current definitions of seroconversion, HIV persistence and remission in children.

Open Forum Infectious DiseasesVol. 13(1)
Délégation Paris 5 (FR), Université d'Orléans (FR), Hôpital Necker-Enfants Malades (FR), Centre National de la Recherche Scientifique (FR), Inserm (FR), Institut Pasteur (FR), Université Paris Cité (FR), Université Paris-Saclay (FR), Sorbonne Paris Cité (FR), Hôpital Cochin (FR), Assistance Publique – Hôpitaux de Paris (FR), Maternité Port Royal (FR), Centre de recherche en Epidémiologie et Santé des Populations (FR), Hôpitaux Universitaires Paris-Ouest (FR), Centre hospitalier universitaire d'Orléans (FR), Hôpital des Enfants (FR), Bicêtre Hospital (FR)
Good health and well-being
Openalex Percentile: Top 31%
HIV Research and Treatment
DOIOpen Access PDFOpenAlex
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Persistent Seronegativity and Absence of Intact Proviruses Despite Prolonged Initial Viremia in Early-Treated Perinatal HIV Infection — Florence Buseyne, S. Blanche, et al. · Open Forum Infectious Diseases (2025) | TGRS Research Map | TGRS