Olink Proteomic Profiling of Vitreous Humor and Plasma From Proliferative Diabetic Retinopathy Patients Identifies a Novel Inflammatory Molecular Endotype
Significant differences in proteomic profiles were observed in PDR patients, especially in vitreous samples, with CA family members identified as potential therapeutic targets for PDR. Endotyping analysis of vitreous samples uncovered unique patient population with enriched CCL/CXCL/IL6/IL18 inflammatory pathways, highlighting the significance of local protein signature changes in PDR disease heterogeneity and its potential applications in patient stratification and therapeutic treatment.
Authors
- H.-Y. Wang (ORCID: https://orcid.org/0000-0003-4431-8849)
- Tian Niu (ORCID: https://orcid.org/0000-0002-0377-3151)
- Jing Wu (ORCID: https://orcid.org/0000-0002-2492-5118)
- X. Hermione Xu (ORCID: https://orcid.org/0000-0001-8682-2969)
- Kangjia Lv
- Xin Dong (ORCID: https://orcid.org/0000-0002-9502-5379)
- Tong Zhang (ORCID: https://orcid.org/0000-0002-0423-7414)
- Kun Liu (ORCID: https://orcid.org/0000-0003-2460-6851)
- Qin Zhang (ORCID: https://orcid.org/0009-0009-5451-4051)
- Qian Zhu (ORCID: https://orcid.org/0000-0001-7062-8221)
- Jiale Peng
- Yu Xiao (ORCID: https://orcid.org/0000-0001-8531-9384)
- Stella Yao
- Rebecca C. Stacy
- Qian Huang
- Yeyu Li
- Xiaoxin Liu
- Yuan Qu
- Ma'en Obeidat
- Yan Jiang
- Xueying Zhou
Institutions
- Novartis (Switzerland) (CH)
- Shanghai Jiao Tong University (CN)
- Novartis (China) (CN)
- Shanghai Eye Disease Prevention & Treatment Center (CN)
- Shanghai First People's Hospital (CN)
- Shanghai Clinical Research Center (CN)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2026-01-21
- DOI
- https://doi.org/10.1167/iovs.67.1.47
- Primary Topic
- Retinal Diseases and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China