A critical review of the methodology of ovine lumbar interbody fusion studies and recommendations for future study design

This review demonstrates variability in the design of ovine LIF studies, highlights features likely to limit the translatability of results into clinical practice (sheep age and interbody cage size), shows high risk of bias in the published literature, and makes recommendations for future studies.

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Publication Details

Journal
Bone and Joint Research
Published
2026-01-21
DOI
https://doi.org/10.1302/2046-3758.151.bjr-2025-0300.r2
Primary Topic
Spine and Intervertebral Disc Pathology
Type
article
Field-Weighted Citation Impact
0.00
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article

A critical review of the methodology of ovine lumbar interbody fusion studies and recommendations for future study design

Kevin M. Shakesheff, Zoya Khan, Jane McLaren, John von Benecke et al.
Bone and Joint Research
Spine and Intervertebral Disc Pathology
article

A critical review of the methodology of ovine lumbar interbody fusion studies and recommendations for future study design

Kevin M. Shakesheff, Zoya Khan, Jane McLaren, John von Benecke, Nick Birch
article en

Abstract

This review demonstrates variability in the design of ovine LIF studies, highlights features likely to limit the translatability of results into clinical practice (sheep age and interbody cage size), shows high risk of bias in the published literature, and makes recommendations for future studies.

Bone and Joint ResearchVol. 15(1)
University of Nottingham (GB), Locate Bio (United Kingdom) (GB), Oxford Technologies (United Kingdom) (GB), Keele University (GB)
Openalex Percentile: Top 83%
Spine and Intervertebral Disc Pathology
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