Etiology of Severe Microcephaly in Infants: A Multinational Surveillance Study
At least one-half of severe microcephaly cases are attributable to genetic causes. One-third had unknown etiology, highlighting a need for a systematic approach to diagnostic investigation, including genomic sequencing and brain imaging for all children with severe microcephaly.
Authors
- Mavis Duncanson (ORCID: https://orcid.org/0000-0003-3845-2961)
- Daniel Farrar
- Carlos Víquez (ORCID: https://orcid.org/0000-0002-3643-1481)
- Clarissa Oeser (ORCID: https://orcid.org/0000-0003-1939-1964)
- Anne Morris
- Ari Bitnun
- Richard Pebody (ORCID: https://orcid.org/0000-0002-9069-2885)
- Rachel L Knowles (ORCID: https://orcid.org/0000-0002-5490-7682)
- E. Elliott
- Charlotte Moore Hepburn
- Shaun K. Morris
- Richard M. Lynn
- Ameenat Lola Solebo
- Gareth Baynam
Institutions
- The University of Sydney (AU)
- Department of Health and Social Care (GB)
- The Kids Research Institute Australia (AU)
- The University of Western Australia (AU)
- University of Toronto (CA)
- Great Ormond Street Hospital (GB)
- Great Ormond Street Hospital for Children NHS Foundation Trust (GB)
- Princess Margaret Hospital for Children (AU)
- Hospital for Sick Children (CA)
- King Edward Memorial Hospital (AU)
- Dunedin Public Hospital (NZ)
- Public Health England (GB)
- Australian Federation of Graduate Women New South Wales (AU)
- Mental Health Commission (IE)
- Institute for Clinical Evaluative Sciences (CA)
- Sydney Children’s Hospitals Network (AU)
- Institute for Work & Health (CA)
- University College London (GB)
- University of Otago (NZ)
Publication Details
- Journal
- PEDIATRICS
- Published
- 2026-01-21
- DOI
- https://doi.org/10.1542/peds.2025-072700
- Primary Topic
- Infectious Encephalopathies and Encephalitis
- Type
- article
- Field-Weighted Citation Impact
- 0.00