Cognitive impairment in comorbid MDD and OSA: the dual effects of intermittent hypoxia and sleep fragmentation
The observed associations between prolonged P300 latency and elevated ODI/Microarousal Index raises the possibility that intermittent hypoxia and sleep fragmentation are underlying contributing factors. These two nocturnal disturbances may interact to worsen cognitive dysfunction in patients with MDD-OSA comorbidity.
Authors
- Tianqin Xie
- Jiakuai Yu
- Jiajia Zhang (ORCID: https://orcid.org/0000-0003-4566-0822)
- Mingming Zheng (ORCID: https://orcid.org/0009-0006-9154-2252)
- Daomin Zhu
- Shuai Ding
- Peng Zhu
- Shuangshuang Ma
Institutions
- Anhui Medical University (CN)
- The Fourth People's Hospital (CN)
- Anhui Mental Health Center (CN)
- Hologic (Germany) (DE)
Publication Details
- Journal
- Frontiers in Psychiatry
- Published
- 2026-01-21
- DOI
- https://doi.org/10.3389/fpsyt.2026.1687180
- Primary Topic
- Obstructive Sleep Apnea Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00