Extracellular vesicle–mediated delivery of miR-181a-3p confers neuroprotection to degenerating retinal ganglion cells
Our findings demonstrate that EVs offer a biocompatible, cell-specific, and functionally effective platform for miRNA delivery to the retina. EV-based administration of miR-181a-3p may represent a novel neuroprotective strategy for glaucoma and related optic neuropathies.
Authors
- Ben Mead (ORCID: https://orcid.org/0000-0001-5855-0097)
- Yasir Ahmed Syed (ORCID: https://orcid.org/0000-0001-9495-307X)
- Esmahan Durmaz
- Kubra Trabzonlu
- Aled Clayton
- Hanady Nehme
- Maryam Esmaeili
- Lydia Alverez-Erviti
Institutions
- Alanya University (TR)
- Center for Biomedical Research of La Rioja (ES)
- Cardiff University (GB)
Publication Details
- Journal
- Experimental Eye Research
- Published
- 2026-01-21
- DOI
- https://doi.org/10.1016/j.exer.2026.110882
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Fight for Sight UK
- Cardiff University