Transcriptomic profiling and machine learning uncover gene signatures of psoriasis endotypes and disease severity
These findings delineate gene-environmental and genetic effects on the psoriasis transcriptome linked to disease severity.
Authors
- Jack Gisby (ORCID: https://orcid.org/0000-0003-0511-8123)
- Rafael Henkin (ORCID: https://orcid.org/0000-0002-5511-5230)
- Deborah D. Stocken (ORCID: https://orcid.org/0000-0001-8031-1738)
- John Casement (ORCID: https://orcid.org/0000-0003-3514-7259)
- Simon Cockell (ORCID: https://orcid.org/0000-0002-6831-9806)
- A. Rider (ORCID: https://orcid.org/0000-0002-1909-1972)
- Graham R. Smith (ORCID: https://orcid.org/0000-0001-6967-7691)
- E. M. Griffiths Christopher
- Amy Foulkes (ORCID: https://orcid.org/0000-0003-2680-750X)
- Henry J. Grantham (ORCID: https://orcid.org/0000-0002-3197-4823)
- Sandra Ng (ORCID: https://orcid.org/0000-0003-4524-6058)
- Kathleen M. Smith (ORCID: https://orcid.org/0000-0001-7833-3102)
- Christopher Traini
- Wasim Iqbal (ORCID: https://orcid.org/0000-0003-3751-9634)
- Paola Di Meglio
- E Thomas
- Tom Ewen (ORCID: https://orcid.org/0009-0007-4028-6698)
- Nick Dand
- Jonathan N. Barker
- Catherine H. Smith
- Michael R. Barnes
- Paolo Zuliani
- Nick J. Reynolds
- Richard B. Warren
- David S. Watson
- Shanker Kalyana-Sundaram
- Shoba Amarnath
- Deepak K. Rajpal
Institutions
- University of Leeds (GB)
- King's College - North Carolina (US)
- Queen Mary University of London (GB)
- King's College London (GB)
- Manchester Academic Health Science Centre (GB)
- University of Manchester (GB)
- AbbVie (United States) (US)
- GlaxoSmithKline (United States) (US)
- NIHR Newcastle Biomedical Research Centre (GB)
- Takeda (United States) (US)
- William Harvey Research Institute (GB)
- NIHR Manchester Biomedical Research Centre (GB)
- Newcastle University (GB)
- Sapienza University of Rome (IT)
Publication Details
- Journal
- Communications Medicine
- Published
- 2026-01-21
- DOI
- https://doi.org/10.1038/s43856-025-01325-4
- Citations
- 1
- Primary Topic
- Psoriasis: Treatment and Pathogenesis
- Type
- article
- Field-Weighted Citation Impact
- 24.43
Funders
- Eli Lilly and Company
- Pfizer
- GlaxoSmithKline
- Celgene
- Queen Mary University of London
- National Institute for Health and Care Research
- British Skin Foundation
- British Association of Dermatologists
- King's College London
- Newcastle University
- Rosetrees Trust
- Stichting Sanquin Bloedvoorziening
- LEO Pharma
- Medical Research Council
- NIHR Newcastle Biomedical Research Centre