Microbiota-dependent transcriptional priming of lung innate immune cells in a mouse model of LPS-induced sepsis-associated lung injury
Commensal microbiota influence transcriptional activity and maturation of pulmonary innate immune cells under experimental conditions, thereby influencing susceptibility to LPS-induced lung injury. Targeting microbiota-guided immune training pathways may allow modulation of pulmonary host defenses.
Authors
- Hirobumi Morisaki (ORCID: https://orcid.org/0000-0001-8415-9083)
- Masayuki Iyoda (ORCID: https://orcid.org/0000-0002-1153-3000)
- Mie Kurosawa (ORCID: https://orcid.org/0000-0002-8348-6311)
- Manami Hayashi (ORCID: https://orcid.org/0009-0005-9968-2818)
- Hirotaka Kuwata (ORCID: https://orcid.org/0000-0002-5023-1777)
- Tomoki Makiura
- Haruka Fukamachi
- Kota Iioka
- Ayako Sato
- Armelia Sari Widyarman
- Hiroki Ishikawa
- Mariko Kikuchi
- Rikuo Masuda
Institutions
- SHOWA Medical University (JP)
- Universitas Trisakti (ID)
- University of Toyama (JP)
Publication Details
- Journal
- Journal of Oral Biosciences
- Published
- 2026-01-21
- DOI
- https://doi.org/10.1016/j.job.2026.100742
- Primary Topic
- Immune Response and Inflammation
- Type
- article
- Field-Weighted Citation Impact
- 0.00