Ultrasound and SNP-based cell-free DNA zygosity testing in twin pregnancies
Based on postpartum placental pathology as the reference standard for determining MC versus DC, cfDNA zygosity testing appears to aid in the prenatal assignment of chorionicity. Larger studies are needed to confirm the value of zygosity testing in the management of twin pregnancies.
Authors
- Neil S. Seligman (ORCID: https://orcid.org/0000-0003-1491-990X)
- Eftichia V. Kontopoulos (ORCID: https://orcid.org/0000-0001-7774-7119)
- Russ Jelsema
- Maeve Hopkins (ORCID: https://orcid.org/0000-0002-1179-3654)
- Homa K. Ahmadzia (ORCID: https://orcid.org/0000-0003-0341-1086)
- Jessica L. Saben (ORCID: https://orcid.org/0000-0002-9873-025X)
- Gerard Reilly
- Sophia Vourthis
- Rubén A. Quintero (ORCID: https://orcid.org/0000-0002-6923-816X)
- Myra Wick (ORCID: https://orcid.org/0000-0003-4126-4523)
- Melissa Egbert (ORCID: https://orcid.org/0000-0003-0708-7498)
- Thomas Westover
- Clark T. Johnson
- Camille Kanaan
- Neeta L. Vora
- Peter Benn
- Ashley Cantu-Weinstein
- K. Joseph Hurt
- Andrei Rebarber
- Vivienne Souter
- Samuel B. Wolf
- Jingwen Zhang
Institutions
- Inova Health System (US)
- Eastern Virginia Medical School (US)
- George Washington University (US)
- Sinai Hospital (US)
- Society for Maternal-Fetal Medicine (US)
- Mount Sinai Hospital (US)
- Fetal Medicine Foundation (GB)
- Collaborative Group (United States) (US)
- Natera (United States) (US)
- Mayo Clinic in Arizona (US)
- Center for Clinical Research (United States) (US)
- Capital Health (US)
- University of Rochester (US)
- University of Colorado Denver (US)
Publication Details
- Journal
- The Journal of Maternal-Fetal & Neonatal Medicine
- Published
- 2026-01-19
- DOI
- https://doi.org/10.1080/14767058.2026.2614840
- Primary Topic
- Assisted Reproductive Technology and Twin Pregnancy
- Type
- article
- Field-Weighted Citation Impact
- 0.00