Unraveling the mechanisms of nicotine-induced osteoporosis via network toxicology, bioinformatics, and molecular docking
This study suggests nicotine exacerbates OP by regulating key targets, such as CASP3 and ESR1, and pathways like apoptosis and estrogen signaling. These findings provide insights into the molecular mechanisms underlying nicotine's role in OP and potential therapeutic targets.
Authors
- Tao Bai
- Jin Liang (ORCID: https://orcid.org/0000-0001-6770-369X)
- Xie Dong
- Xiongwen Zhang (ORCID: https://orcid.org/0000-0002-6514-4190)
- Song Xu
- Jiaxin Liu
- Guozhu Wang
Institutions
- Kunming University of Science and Technology (CN)
- Kunming Medical University (CN)
- Sixth Affiliated Hospital of Kunming Medical University (CN)
Publication Details
- Journal
- Tobacco Induced Diseases
- Published
- 2026-01-20
- DOI
- https://doi.org/10.18332/tid/215177
- Primary Topic
- Nicotinic Acetylcholine Receptors Study
- Type
- article
- Field-Weighted Citation Impact
- 0.00