Medication Adherence in the Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness Study (GRADE)

Medication adherence was consistently high in GRADE. Observed treatment group differences were small and of unclear clinical significance. Overall, lower adherence robustly predicted worsening glycemic control, highlighting the importance of ongoing assessment.

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Journal
Diabetes Care
Published
2026-01-20
DOI
https://doi.org/10.2337/dc25-2008
Primary Topic
Medication Adherence and Compliance
Type
article
Field-Weighted Citation Impact
0.00

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article

Medication Adherence in the Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness Study (GRADE)

E.J. Boyko, Caroline Presley, Gladys Crespo-Ramos, M.R. Gramzinski et al.
Diabetes Care
Medication Adherence and Compliance
article

Medication Adherence in the Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness Study (GRADE)

E.J. Boyko, Caroline Presley, Gladys Crespo-Ramos, M.R. Gramzinski, Diane Uschner, CJ Buys, NICOLE M. BUTERA, Basma N. Fattaleh, Claire J. Hoogendoorn, Violet S. Lagari, Elizabeth A. Walker, K.J. Mather, J.P. Crandall, Hui Wen, H.J. Meléndez Flórez, Juana Gonzalez, Helen Petrovitch, HM Ismail, EC Tsai, D. Lorber, G. Fuller, E. Cline, C. Carlson, W.L. Fein, A. Ghosh, D. Juarez, J.J. Craine, P. Wilson, A. Bancroft, K. Kersey, D. Hernandez McGinnis, M. Perez, K. Whitley, P. Copeland, L.L. Thomas, N. Thangthaeng, L. Lysne, M. Lee, T. Killean, B. Steiner, Y.J. Kendal, M. Rhee, E. LaSalle, G. Riera, A. Kozedub, L. Holloway, J. Hyatt, J. Criscola, D. Culmer, J. Bethepu, A. Kirpitch, S. Duran, E. Schroeder, K.M. Atkinson, L. Tucker, B. Pucchetti, E.R. Seaquist, S. Gonzalez de la torre, R. Fraser, J. Leger, M. Abdul-Ghani, A. Waltje, K. Seipel, A. Ideozu, R. Eggleston, D. Lorber, R.A. DeFronzo, B. Kauffman, J. Bantle, H. H. Liu, R.M. Cohen, P. Kringas, L. Savoye, E. Gonzalez Hattery, S. Person, N. Patel, R. Gaba, M. Razzaghi, J. Kerr, C. Suratt, Deborah J. Wexler, C. Hazlett, C. Jensen, M. Mullen, T. Onadeko, S. Nazarov, C. Wilson, C. Lund, H. Verastiqui, G. Lord, S. Abraham, L. Morton, C. Baker, M. Gutt, K. Martin, H. Schneier, O. Griffith, B. Gildersleeve, G. Fuller, M. Madden, R.R. Ishii, A. Goley, C. Puckett, C. Sandsers, K. Pham, M.B. Vonder Meulen, L. Ngo, Heidi Krause-Steinrauf, R. Passi, J. Park, J. Steppel-Reznik, V. Pirics, H. Almeida, C. Adams, W. Taylor, V. Ripley, S. McCullars, M.D. McKee, R. Goland, K. Mularski, L. Hope, L.F. Jordan, L. Colosimo, A. Adolphe, L. Alfano, E. Burgess, J. Gluth, L. Manandhar, M. Johnson, E. Schield, N. Younes, L. Gurry, B. Torgrimson-Ojerio, N.O. Bermudez, C.A. White, S.H. Hox, V. Jenkins, E. Joshevama, S. Lipp, L. Osornio Walker, J. Boers, M. Magee, E. Cline, S. Yang, S. Tanukonda, S. Machineni, M. Tsovian, D. Dyer, R. Garg, P. Brantley, D. Gabrielson, H. Estrella, M. Hurtado, T. Concepcion, N. Butera, T. Karshner, R. Hill, P. McGee, K. Berame, K. Bergamo, L. Soni, C. Carlson, D.S. Hsia, S. Bule, B. Ash, W.T. Cefalu, E. Raymond, S. Steiner, E. Kazemi, A.L. Morales, A. Zamorano, V. Lagari-Libhaber, S. Warren, M. Matwichyna, M.V. Kononets, R. Tillson, K.M. Utzschneider, B. Bourgeois, J. Day, J. Huminik, A. Taddese, A. Kumar, M.M. Mishko, M. Tripputi, V. Meiners, R.B. Kreymer, L. Broadwater, W.H. Herman, A. Saenger, M. Hillard, A. Ressing, S. Fortmann, N. Kessler, K. Kleeberger, F. Ismail-Beigi, C. Gullett, N. Rasouli, A. Maxwell, T. Kulow, L. Alarcon-Casas Wright, N. Prikhodko, I. Bebu, G. Fry, J.M. Lachin, J.B. Buse, P. August, S. Hurt, D. Wexler, K. Lessard, S. Casula, A.K. Riccio Veliz, J. Diner, B. Cramer, A. Agne, D. Sturgess, B.N. Fattaleh, A. Dushkin, J.E. Park, J. Seegmiller, F.L. Greenway, C. Lyon, E. Mesimer, J. Prihoda, K. Wright, M.G. Rodriguez, S. Golden, J. Fradkin, J. Lukin, L.S. Phillips, C. Falck-Ytter, C. Rhee, J. Meigs, L. Kiker, J. Iacoboni, M.C.R. Lawson, K. Arnold, H. O’Neal, A. Kuhn, I. Abdouch, W. Tamborlane, C. Underkofler, J. Krakoff, M. Jackson, K. Josey, F.E. Broyles, E. Diaz, O. Smith, A. Turchin, K. Ballentine-Cargill, J. Marks, R. Meiners, E. Sledge Jr., M. Herson, T. Lowe, S. Sao, J. Costello, C. Stevens, A.L. Cherrington, A. Werner, P. Gatcomb, E. Xhori, R. Nieto-Martinez, A. Cherian, R. Mungara, N. Haynes, G. Rocchio, E. Duran-Valdez, H. Glauber, C. Newman, T. Harindhanavudhi, R. Pop-Busui, C. Waguespack, M.H. Jacobson, D. Juarez, M. Burge, A. Carlson, F. Morehead, J. Craig, A. Alfred, S. Smith, R. Penaloza, T. Hamilton, H. Dulin, P. Raskin, A. Gliwa, M. Khalid, C. Patel, M.E. Larkin, M. Coe, S. Guarda, J. Pring, R. Kochis, J. Jimenez, Y. N. Gao, A. Ghosh, M.C. Rogge, J. Eggert, M. Steffes, C. Hausheer, S. Douglass, G. Canaris, W.I. Sivitz, M. Pavlionis, J. Tejada, J. McConnell, S.D. Hall, D.M. Nathan, B. Veciana, A. Montosa, K. Chu, C. Desouza, V. Aroda, J.M. Curtis, S.E. Inzucchi, Andrea L. Cherrington, S. Rhothisen, S. Morton, K. Burton, E. Legowski, W. Konerza, S. Coffer, K. Bays, M. Hamm, E. Panos, E. Debnam, A. Bantle, T. Conner, K. Schell, A. Camp, S. Behringer-Massera, K.A. Stancil, L. Young, M. Tiktin, W.M. Valencia, A. Thomassie, C. Triplitt, G. Bahtiyar, B. Chambers, T. Martens, P. Mangat Dhaliwal, L. Iannone, V. Arends, C. Wright, H.B. Burch, V. Shivaswamy, S. Kuo, A. Cuadot, A. Naik, M. Alguard, C.N. Mariash, J. Brown-Friday, S.E. Kahn, K. Gumpel, O. Sanchez, A. Sood, J.F. Largay, J. Dostou, H. Willis, L. Oropesa-Gonzalez, T. Young, D. Ghioni, S. Bojescu, A. Sacerdote, R. Ayala, D. Howard, H. Krause-Steinrauf, R. Lorch, A. DeManbey, L. Sayyed Kassem, L. Kuechenmeister, J. Arceneaux, E. Magenheimer, L. Schnurr-Breen, L. Hue, A. Dragg, D. Martin, R. Bergenstal, A. Loveland, T.S. Raines, J. Cook, M. Sibymon, D. Aguillar, K. Tsingine, M. Maher-Albertelli, F. Mwicigi, G. Montes, F. Ali Jamaleddin Ahmad, A. Lteif, S. Sahnow, M. Cayford, M.S. Lee, E. Scripsick, C. Friason, C. Adkins, G. McPhee, A.A. Bremer, L. Goodhall, S. Trikudanathan, A. Scrymgeour, D. Olson, M. Backman, A. Ghazi, D.H. Josephson, C. Moak, A. Krol, E. King, M. Mech, E. Cersosimo, A. Katona, A. Balasubramanyam, M.A. Banerji, M.S. Kirkman, M.H. Tan, S. Burbach, A. Fagan, A. Arey, C. Martin, B.K. Montgomery, J. Marco Martínez, A. Ross, D.S. Schade, S. Kunkel, J. Cuffee, B. Redmon, M. Yepes, S. Jones, B. Gulanski
article en

Abstract

Medication adherence was consistently high in GRADE. Observed treatment group differences were small and of unclear clinical significance. Overall, lower adherence robustly predicted worsening glycemic control, highlighting the importance of ongoing assessment.

Diabetes CareVol. 49(2)
Albert Einstein College of Medicine (US), Milken Institute (US), Yeshiva University (US), University of Alabama at Birmingham (US), Massachusetts General Hospital (US), VA Puget Sound Health Care System (US), VA Pacific Islands Health Care System (US), Miami VA Healthcare System (US)
American Diabetes Association, U.S. Department of Veterans Affairs, Bristol-Myers Squibb, Sanofi, Vanderbilt University, BD, Novo Nordisk, National Institutes of Health, Centers for Disease Control and Prevention, National Heart, Lung, and Blood Institute, National Institute of Diabetes and Digestive and Kidney Diseases
Openalex Percentile: Top 84%
Medication Adherence and Compliance
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