A first‐trimester mechanistic framework integrating three Physiopathologic biomarker domains for pre‐eclampsia classification
A first-trimester, mechanistic three-domain framework captures the pathophysiologic continuum of placental insufficiency and supports accurate, clinically meaningful early risk stratification for PE. Findings were internally validated; external validation-particularly for early-onset PE-is warranted.
Authors
- Elsa Romelia Moreno‐Verduzco (ORCID: https://orcid.org/0000-0002-8733-1800)
- Lourdes Rojas‐Zepeda (ORCID: https://orcid.org/0000-0002-1801-9653)
- Javier Perez Duran
- Johnatan Torres‐Torres
- Salvador Espino‐y‐Sosa
- Juan Mario Solis‐Paredes
- Hector Borboa‐Olivares
- Irma Eloisa Monroy‐Muñoz
- Raigam Jafet Martinez‐Portilla
Institutions
- Universidad Iberoamericana (MX)
- Instituto Nacional de Perinatología (MX)
- Instituto de Salud del Estado de México (MX)
Publication Details
- Journal
- International Journal of Gynecology & Obstetrics
- Published
- 2026-01-19
- DOI
- https://doi.org/10.1002/ijgo.70804
- Primary Topic
- Pregnancy and preeclampsia studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00