Research status and prospects of molecular pathological mechanisms and novel therapeutic targets of osteosarcoma: a systematic review
Future directions require integrating AI-driven imaging omics, spatiotemporal multi-omics, and mechanically adaptive biomaterials to establish a precision management system. This will advance osteosarcoma therapy from survival prolongation toward functional cure-defined as complete tumour eradication with physiological reconstruction of bone structure/function (e.g., restoring load-bearing/joint mobility), while preventing treatment-related disability, ultimately achieving oncologic cure with preserved quality of life.
Authors
- Huan Jin (ORCID: https://orcid.org/0000-0001-5886-7481)
- Chen Ma
- Cai Huang
- Li Shen (ORCID: https://orcid.org/0000-0002-0069-1310)
- Yu Shang
- Qi Xiong (ORCID: https://orcid.org/0000-0001-7326-0821)
- Zixian Wang (ORCID: https://orcid.org/0000-0002-8781-4298)
- Lingfeng Zeng (ORCID: https://orcid.org/0000-0003-2631-3593)
- Ying Dong
- Siwei Shi
- Bo Shuai
- Di Wang
- Ziyi He
Institutions
- Guangzhou University of Chinese Medicine (CN)
- Hubei Provincial Women and Children's Hospital (CN)
- Huazhong University of Science and Technology (CN)
- Wuhan Sports University (CN)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2026-01-20
- DOI
- https://doi.org/10.3389/fonc.2025.1665299
- Primary Topic
- Sarcoma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China