Structural Insights into the Interaction Between a Core-Fucosylated Foodborne Hexasaccharide (H2N2F2) and Human Norovirus P Proteins
This work provides a large-scale structural and energetic assessment of the potential interactions between a naturally occurring lettuce-derived fucosylated hexasaccharide and human norovirus P domains. The results support the notion that core-fucosylated food-associated glycans can serve as interaction partners for diverse norovirus genotypes and offer comparative molecular insights into glycan recognition patterns relevant to foodborne transmission. The integrative AlphaFold3-docking-dynamics framework presented here may facilitate future investigations of virus-glycan interactions within food matrices.
Authors
- Liang Xue
- Danlei Liu (ORCID: https://orcid.org/0000-0001-6208-6354)
- Jiaqi Xu (ORCID: https://orcid.org/0000-0002-2774-5016)
- Yuchen Wang (ORCID: https://orcid.org/0000-0001-8494-6124)
- Ye Lu (ORCID: https://orcid.org/0000-0003-3982-7331)
- Shumin Li
- Zilei Zhang
- Justin Troy Cox
Institutions
- Jilin University (CN)
- Shenzhen International Travel Health Care Center (CN)
- Shanghai Customs College (CN)
- Guangdong Academy of Sciences (CN)
- Shandong Mental Health Center (CN)
- Institute of Microbiology (CN)
- Obstetrics and Gynecology Hospital of Fudan University (CN)
- Imagination Engines (United States) (US)
Publication Details
- Journal
- Viruses
- Published
- 2026-01-20
- DOI
- https://doi.org/10.3390/v18010131
- Primary Topic
- Viral gastroenteritis research and epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Shanghai Rising-Star Program
- State Key Laboratory of Advanced Metallurgy