Respiratory and cardiac toxicity of xylazine and fentanyl overdose in rats

Xylazine significantly potentiates fentanyl-induced respiratory depression and cardiovascular collapse in a dose-dependent manner in rats.

Authors

Tristan H. Lewis (ORCID: https://orcid.org/0000-0001-9697-5045)
Annick Haouzi (ORCID: https://orcid.org/0000-0001-5279-5309)
Philippe Haouzi (ORCID: https://orcid.org/0000-0002-8181-4254)
Amanda Reinhardt

Institutions

Cleveland Clinic (US)
Case Western Reserve University (US)

Publication Details

Journal: Clinical Toxicology
Published: 2026-01-20
DOI: https://doi.org/10.1080/15563650.2025.2598328
Primary Topic: Veterinary Pharmacology and Anesthesia
Type: article
Field-Weighted Citation Impact: 0.00

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article

Respiratory and cardiac toxicity of xylazine and fentanyl overdose in rats

Tristan H. Lewis, Annick Haouzi, Philippe Haouzi, Amanda Reinhardt

Jan 20, 2026

Clinical Toxicology

Veterinary Pharmacology and Anesthesia

article

Respiratory and cardiac toxicity of xylazine and fentanyl overdose in rats

Tristan H. Lewis, Annick Haouzi, Philippe Haouzi, Amanda Reinhardt

January 20, 2026article en

Abstract

Xylazine significantly potentiates fentanyl-induced respiratory depression and cardiovascular collapse in a dose-dependent manner in rats.

Clinical ToxicologyVol. 64(3)

Cleveland Clinic (US), Case Western Reserve University (US)

Good health and well-being

Openalex Percentile: Top 83%

Veterinary Pharmacology and Anesthesia

DOI Source OpenAlex

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Respiratory and cardiac toxicity of xylazine and fentanyl overdose in rats — Tristan H. Lewis, Annick Haouzi, et al. · Clinical Toxicology (2026) | TGRS Research Map | TGRS