Impact of carbon-ion radiotherapy on tumor hypoxia detected by 18F-FMISO PET/CT in locally advanced non-small cell lung cancer
Tumor hypoxia detected by <sup>18</sup>F-FMISO PET/CT was significantly decreased after CIRT in patients with LA-NSCLC. Similar LC was achieved in patients with or without pre-CIRT hypoxia, while post-CIRT hypoxia clearance resulted in a non-significant trend toward improved LC. Combining <sup>18</sup>F-FMISO and <sup>18</sup>F-FDG PET/CT might provide enhanced prognostic value. Further investigation is warranted to explore individualized CIRT dose painting strategies guided by multi-tracer PET/CT imaging.
Authors
- K. Wu
- G. Jiang
- J Chen
- Ningyi Ma
- JingYi Cheng
- Jingfang Mao
Institutions
- Fudan University Shanghai Cancer Center (CN)
Publication Details
- Journal
- European Journal of Nuclear Medicine and Molecular Imaging
- Published
- 2026-01-20
- DOI
- https://doi.org/10.1007/s00259-025-07702-4
- Primary Topic
- Cancer, Hypoxia, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Shanghai Municipal Health Commission
- Shanghai Pudong New Area Health Commission