Molecular Analysis Based on Fine-Needle Aspiration Washout Samples in Thyroid Nodules
Our findings extend current diagnostic approaches by showing that dual-gene (BRAF and RAS) testing from fresh FNA washouts is technically feasible (≥90% adequacy) and provides high specificity with modest sensitivity for malignancy in indeterminate nodules. In settings lacking comprehensive commercial panels, this low-complexity approach offers a practical adjunct to cytology and imaging for preoperative decision-making.
Authors
- Bekir Çakır (ORCID: https://orcid.org/0000-0001-7526-8827)
- Cevdet Coşkun AYDIN (ORCID: https://orcid.org/0000-0003-2064-6936)
- Gulsum Karahmetli
- Şefika Burçak Polat (ORCID: https://orcid.org/0000-0002-7729-5586)
- Bülent Çomçalı
- Ahmet Cevdet Ceylan
- Mustafa Altan
- Oya Topaloğlu
- Reyhan Ersoy
- Sevgül Fakı
Institutions
- Ankara University (TR)
- Bilkent University (TR)
- Memorial Ankara Hospital (TR)
- Ankara Numune Eğitim ve Araştırma Hastanesi (TR)
- Başkent University Hospital (TR)
Publication Details
- Journal
- Genes
- Published
- 2026-01-19
- DOI
- https://doi.org/10.3390/genes17010099
- Primary Topic
- Thyroid Cancer Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00