Monthly multiple injections of leukocyte-poor platelet-rich plasma (ACP®) for knee osteoarthritis: clinical effectiveness across KL grades, dose-response plateau at four, and 24-month durability

Under a fixed monthly protocol mirroring our LR-PRP schedule, ACP (LP-PRP) produced clinically meaningful improvements across KL1-4 with a practical evaluation horizon through the 4th injection and no clear per-session volume benefit of 6 mL over 3 mL. Prospective randomization of dose within a monthly-multiple framework is warranted.

Authors

Publication Details

Journal
Regenerative Therapy
Published
2026-01-20
DOI
https://doi.org/10.1016/j.reth.2026.101067
Primary Topic
Periodontal Regeneration and Treatments
Type
article
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article

Monthly multiple injections of leukocyte-poor platelet-rich plasma (ACP®) for knee osteoarthritis: clinical effectiveness across KL grades, dose-response plateau at four, and 24-month durability

Masahiko Kemmochi
Regenerative Therapy
Periodontal Regeneration and Treatments
article

Monthly multiple injections of leukocyte-poor platelet-rich plasma (ACP®) for knee osteoarthritis: clinical effectiveness across KL grades, dose-response plateau at four, and 24-month durability

Masahiko Kemmochi
article en

Abstract

Under a fixed monthly protocol mirroring our LR-PRP schedule, ACP (LP-PRP) produced clinically meaningful improvements across KL1-4 with a practical evaluation horizon through the 4th injection and no clear per-session volume benefit of 6 mL over 3 mL. Prospective randomization of dose within a monthly-multiple framework is warranted.

Regenerative TherapyVol. 31
No poverty
Openalex Percentile: Top 84%
Periodontal Regeneration and Treatments
DOIOpen Access PDFOpenAlex
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Monthly multiple injections of leukocyte-poor platelet-rich plasma (ACP®) for knee osteoarthritis: clinical effectiveness across KL grades, dose-response plateau at four, and 24-month durability — Masahiko Kemmochi · Regenerative Therapy (2026) | TGRS Research Map | TGRS