A Comprehensive Review on Medicinal Value and Pharmacological Profile of Simarouba Amara [Abul]

Simarouba amara is a tree species from the Simaroubaceae family, native to the rainforests, savannahs, and Caribbean regions of Central and South America. This study provides a comprehensive review of the medicinal and pharmacological profile of S. amara. The plant's leaves and bark have been traditionally used to treat various ailments, including malaria, diarrhea, and dysentery 1. Phytochemical analysis reveals the presence of quassinoids, a class of triterpenes, which are responsible for the plant's therapeutic properties. Some of them are Ailanthinone, glaucarubinone, and holacanthone which are the principle biologically active phytochemical constituents present in S. amara. It possesses therapeutic qualities; Pharmacologically have been employed as an “anthelminthic, anticancer, anti-inflammatory, antiviral, anorectic, tonic, insecticide, antimalarial, antimicrobial, anti-amoebic, hepatoprotective, analgesic, antipyretic, antidiarrheal, anti-bacterial, gastroprotective, antileukemic, astringent, febrifuge and skin hydrator”. Keywords: <i>Simarouba amara</i>, Pharmacological activities, Phytochemical analysis, Medicinal value