HyKid: An Open MRI Dataset with Expert-Annotated Multi-Structure and Choroid Plexus in Pediatric Hydrocephalus

Evaluation of hydrocephalus in children is challenging, and the related research is limited by a lack of publicly available, expert-annotated datasets, particularly those with segmentation of the choroid plexus. To address this, we present HyKid, an open-source dataset from 48 pediatric patients with hydrocephalus. 3D MRIs were provided with 1mm isotropic resolution, which was reconstructed from routine low-resolution images using a slice-to-volume algorithm. Manually corrected segmentations of brain tissues, including white matter, grey matter, lateral ventricle, external CSF, and the choroid plexus, were provided by an experienced neurologist. Additionally, structured data was extracted from clinical radiology reports using a Retrieval-Augmented Generation framework. The strong correlation between choroid plexus volume and total CSF volume provided a potential biomarker for hydrocephalus evaluation, achieving excellent performance in a predictive model (AUC=0.87). The proposed HyKid dataset provided a high-quality benchmark for neuroimaging algorithms development, and it revealed the choroid plexus related features in hydrocephalus assessments.<br>Our datasets are publicly available at <a href='https://www.synapse.org/Synapse:syn68544889'>https://www.synapse.org/Synapse:syn68544889</a> and <a href='https://github.com/yunzxu/HyKid'>https://github.com/yunzxu/HyKid</a>