Transoral surgery for hypopharyngeal and laryngeal cancers in Japan: Current status from a nationwide multicenter retrospective study
Non-robot-assisted TOS demonstrated excellent oncologic control and functional preservation of the larynx with low complication rates in early-stage hypopharyngeal and laryngeal cancers. Each surgical modality has distinct indications depending on the tumor site, depth of invasion, and institutional expertise. These findings support the use of TOS as a safe and effective treatment option for selected patients. Further procedural standardization and data accumulation are required to refine the indications and facilitate their broader adoption in clinical practice.
Authors
- Takashi Mukaigawa (ORCID: https://orcid.org/0000-0001-9804-7154)
- Daisuke Sano
- Seiichi Yoshimoto (ORCID: https://orcid.org/0000-0001-9270-095X)
- Ryuichi Hayashi
- Hirohito Umeno
- Takahiro Asakage
- Kazunori Fujiwara (ORCID: https://orcid.org/0000-0001-5676-3275)
- Chieko Yokota (ORCID: https://orcid.org/0009-0000-8810-6085)
- Ichiro Tateya (ORCID: https://orcid.org/0000-0003-4737-4811)
- Megumi Kitayama (ORCID: https://orcid.org/0009-0002-2396-4622)
- Munenaga Nakamizo
- Naoki Nishio (ORCID: https://orcid.org/0009-0001-8026-2080)
- Daizo Murakami
- Mitsuhiko Nakahira (ORCID: https://orcid.org/0000-0003-4059-1960)
- Kenzo Ohara (ORCID: https://orcid.org/0000-0002-6957-6206)
- 渡邉 昭仁
- Ryo Asato
- Masami Osaki
- Nobuhiro Hanai
- Shun-ichi Chitose
- Akihiro Shiotani
- Koji Araki
- Kazuto Matsuura
- Hiroki Mitani
- Ken-ichi Nibu
- Takahiro Tsujikawa
- Tomoyuki Arai
- Masayuki Tomifuji
- Kenji Okami
- TAKASHI Fujii
- Kosuke Uno
- Yuki Saito
- Masahiro Kikuchi
- Koichi Kano
- Daisuke Kawakita
- Takayuki Imai
Institutions
- Kurume University (JP)
- Tokyo Institute of Technology (JP)
- Tokai University (JP)
- Fujita Health University (JP)
- Asahikawa Medical University (JP)
- Chiba University (JP)
- Wakayama Medical University (JP)
- Kyoto Medical Center (JP)
- Nagoya City University (JP)
- Kyoto Prefectural University of Medicine (JP)
- National Defense Medical College Hospital (JP)
- Tokyo Institute of Psychiatry (JP)
- Shizuoka Cancer Center (JP)
- Miyagi Prefectural Hospital Organization (JP)
- Nagoya City University Hospital (JP)
- Tokai University Hospital (JP)
- Tottori University Hospital (JP)
- Keiyukai Sapporo Hospital (JP)
- Aichi Cancer Center (JP)
- The Cancer Institute Hospital (JP)
- National Cancer Center Hospital East (JP)
- Osaka International Cancer Institute (JP)
- Hakodate Central General Hospital (JP)
- Nippon Medical School Hospital (JP)
- Tokyo National Hospital (JP)
- Kobe City Medical Center General Hospital (JP)
- Hyogo Prefectural Cancer Center (JP)
- Japanese Foundation For Cancer Research (JP)
- Tottori University (JP)
- National Defense Medical College (JP)
- Nagoya University (JP)
- Kitasato University (JP)
- Kobe University (JP)
- Tokyo Metropolitan University (JP)
- The University of Tokyo (JP)
- Nippon Medical School (JP)
- Saitama Medical University (JP)
- Yokohama City University (JP)
- Kumamoto University (JP)
Publication Details
- Journal
- Auris Nasus Larynx
- Published
- 2026-01-20
- DOI
- https://doi.org/10.1016/j.anl.2025.12.015
- Primary Topic
- Head and Neck Cancer Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00