Blood and imaging biomarkers of blood-brain barrier disruption in diabetic individuals with cognitive impairment
Our results confirm the critical role of BBB dysfunction in diabetic cognitive impairment. The biomarkers serum PDGFRβ, Ktrans, and Ve showed potential associations with this condition, suggesting their clinical value for future clinical application in risk stratification and therapeutic monitoring in T2DM population. TRN: ChiCTR2400085417, 2024.06.06, retrospectively registered.
Authors
- Qing Xie (ORCID: https://orcid.org/0000-0002-4901-4134)
- Xinyue Chen (ORCID: https://orcid.org/0000-0002-5439-2295)
- Luyao Qiao
- Mengqian Wu
- Zhenyu Tang (ORCID: https://orcid.org/0000-0003-4728-3397)
- Jiaxing Peng (ORCID: https://orcid.org/0000-0003-0045-1808)
- Xiaoping Tang
Institutions
- Nanchang University (CN)
- First Affiliated Hospital of Jiangxi Medical College (CN)
- Second Affiliated Hospital of Nanchang University (CN)
- Second Hospital of Nanchang (CN)
Publication Details
- Journal
- Aging Clinical and Experimental Research
- Published
- 2026-01-20
- DOI
- https://doi.org/10.1007/s40520-025-03316-w
- Primary Topic
- Barrier Structure and Function Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00