Effect of protein-rich diet and the tamarind trypsin inhibitor on behavioral disorders in obese zebrafish
Despite these findings, no consistent behavioral alterations indicating anxiety, sociability issues, or stress responses were associated with overfeeding or TTI. Thus, TTI did not induce behavioral side effects and may be a promising candidate for obesity treatment, differing from many current pharmacological options. Given the translational relevance of zebrafish to human nutrition and health, these findings highlight the potential of TTI as a candidate bioactive compound for future dietary interventions targeting both metabolic and behavioral outcomes in obesity.
Authors
- Ana Heloneida de Araújo Morais (ORCID: https://orcid.org/0000-0002-6460-911X)
- Isaiane Medeiros (ORCID: https://orcid.org/0000-0003-4541-3952)
- Aslan Costa Trajano
- Juliana Kelly da Silva-Maia (ORCID: https://orcid.org/0000-0002-7970-534X)
- Larissa Aida Lemos de Souza
- Aline Lopes Marques de Sousa
- João Paulo Mamede
- Amanda Maria de Souza Nascimento
- Thaiz Ivana da Silva Costa
- Ana Karoliny Xavier de Gois Silva
Institutions
- Universidade Federal do Rio Grande do Norte (BR)
Publication Details
- Journal
- Frontiers in Nutrition
- Published
- 2026-01-20
- DOI
- https://doi.org/10.3389/fnut.2025.1706938
- Primary Topic
- Zebrafish Biomedical Research Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Universidade Federal do Rio Grande do Norte