Endothelial cells protect Schistosoma mansoni from hydrogen peroxide-induced death
Endothelial cells may play a key role in protecting S. mansoni against host oxidative defenses. Dapsone hydroxylamine interferes with this protection by inhibiting catalase activity. These findings point to potential therapeutic strategies targeting the host-parasite interface and the antioxidant environment in schistosomiasis.
Authors
- Juliana Bezerra Dória Lima
- Kelvin Edson Marques de Jesus (ORCID: https://orcid.org/0009-0005-9481-6848)
- Karine Araújo Damasceno (ORCID: https://orcid.org/0000-0003-2087-1690)
- Fernanda Freitas Costa
- Marilda de Souza Gonçalves (ORCID: https://orcid.org/0000-0003-3000-1437)
- Ricardo Riccio Oliveira (ORCID: https://orcid.org/0000-0001-9586-2313)
- Sânzio Silva Santana
- Dalila Lucíola Zanette (ORCID: https://orcid.org/0000-0001-9397-4127)
- Isadora Cristina de Siqueira (ORCID: https://orcid.org/0000-0002-2520-4099)
- Andressa Moreira Lima
- Thassila Nogueira Pitanga
- Camilla Almeida Menezes
- Brenda Rodrigues Brito Cunha Silva
- Lorena Conceição de Queiroz
- Bruna Oliveira Lopes Souza
- Ronald Alves dos Santos
Institutions
- Fundação Oswaldo Cruz (BR)
Publication Details
- Journal
- PLoS neglected tropical diseases
- Published
- 2026-01-20
- DOI
- https://doi.org/10.1371/journal.pntd.0013923
- Primary Topic
- Parasites and Host Interactions
- Type
- article
- Field-Weighted Citation Impact
- 0.00