The Rise of Biomimetic Strategies and Materials in Restorative Dentistry and Endodontics - Review

Abstract The convergence of biology and materials science has catalyzed a transformative approach in dentistry—biomimetics—where restoration and regeneration are guided by the principles of natural tissue architecture and function. This review examines the progressive integration of biomimetic strategies in restorative and regenerative dentistry, emphasizing the role of bioactive materials such as calcium silicate-based cements, bioactive glass, and peptide-functionalized scaffolds. These innovations replicate the hierarchical structure of enamel and dentin while promoting remineralization, cellular differentiation, and tissue repair. Emerging technologies in tissue engineering and nanomaterials have enabled the development of self-healing composites and smart adhesives that adapt to the oral microenvironment. By harmonizing synthetic interventions with biological models, biomimetic dentistry advances a minimally invasive, longevity-driven paradigm that enhances clinical outcomes. This synthesis highlights the translational potential of biomimetic materials in preserving pulp vitality, optimizing aesthetics, and restoring functional integrity.