Adjuvant radiotherapy for patients with clinical T3–4 oral and oropharyngeal cancer who achieved major pathologic response after neoadjuvant immunochemotherapy and surgery: a propensity score-matched retrospective study
Omitting ART in patients with cT3-4 OC/OPC who achieve MPR after neoadjuvant immunochemotherapy and surgery significantly compromises oncological outcomes. Further investigation is necessary to optimize adaptive de-escalation strategies for this population.
Authors
- Wanming Hu
- C. Chen (ORCID: https://orcid.org/0000-0001-6982-2377)
- J. G. Lu (ORCID: https://orcid.org/0009-0007-2893-1770)
- Mengya Du
- Yani Zhang (ORCID: https://orcid.org/0000-0002-5888-3390)
- Shida Yan
- Chulin Yang
- Liji Zheng
- Xianlu Gao
- Menghua Li
- Shiyan Yang
- Shuwei Chen
- Lili Liu
- Ming Song
- Jian Zhou
Institutions
- Sun Yat-sen University (CN)
- Sun Yat-sen University Cancer Center (CN)
- State Key Laboratory of Oncology in South China
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-01-20
- DOI
- https://doi.org/10.3389/fimmu.2025.1681587
- Primary Topic
- Head and Neck Cancer Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Guangdong Province