Triglyceride-glucose-related indices and cardiovascular outcomes in individuals with pre-frailty or frailty: insights from a prospective cohort analysis using UK Biobank data

TyG-related indices, particularly TyG-WC and TyG-BRI, were independently associated with cardiovascular morbidity and mortality in pre-frail or frail individuals. These indices may serve as simple, scalable tools for identifying cardiovascular risk in pre-frail or frail individuals. Mediation analyses highlight potential avenues for targeted interventions aimed at reducing cardiovascular risk.