Epidemiology and outcome of intra-abdominal infections in intensive care unit in Italy from the Italian Register of complicated Intra-abdominal InfectionS—the IRIS study: a prospective observational nationwide study
Septic shock remains the leading cause of ICU admission in patients with IAIs. Patients with immunosuppression, serious cardiovascular comorbidities, requirement for re-operation, inadequate source control, peritonitis, and healthcare-associated infections were at significantly higher risk of in-hospital mortality. Overall, our study reinforces the multifactorial nature of mortality in critically ill patients with intra-abdominal infections, highlighting modifiable factors (source control, timely intervention) that can be targeted to improve outcomes.
Authors
- Alessandra Risso
- Francesco Paolo Prete (ORCID: https://orcid.org/0000-0003-0426-8752)
- Noemi Di Fuccia
- Lorenzo Ghiadoni (ORCID: https://orcid.org/0000-0002-7399-2720)
- F. Forfori
- Stefano Perrone
- Matteo Nardi
- Etrusca Brogi (ORCID: https://orcid.org/0000-0001-9010-7941)
- Alberto Vannelli (ORCID: https://orcid.org/0000-0002-8894-5361)
- Filippo Vagelli
- Elena Schembari (ORCID: https://orcid.org/0000-0003-1393-2707)
- Jacopo Giuliani (ORCID: https://orcid.org/0000-0003-4096-2514)
- Alessandro Cipriano (ORCID: https://orcid.org/0000-0001-7085-3621)
- F. Coccolini
- Ettore Melai
- Eugenio Cucinotta (ORCID: https://orcid.org/0000-0002-2749-3971)
- Dario Tartaglia
- Mr. Marco Anania
- Michele Altomare
- Nita Gabriela Elisa
- Mauro Podda
- Mario Testini
- Marco Milone
- Fausto Catena
- Vittoria Giovane
- Roberta Gelmini
- Andrea Spota
- Francesco Virdis
- Marco Ceresoli
- Lorenzo Gamberini
- Camilla Cremonini
- Stefano Scabini
- Giacomo Carganico
- Emanuele Doria
- Elia Giuseppe Lunghi
- Angela Gurrado
- Riccardo Guelfi
- Francesco Arces
- Massimo Chiarugi
- Maria Grazia Sibilla
- Michela Giulii Capponi
- Massimo Sartelli
- Giulia Ciabatti
- Stefania Cimbanassi
- Luigi Romeo
- Luigi Cobuccio
- Rosa Scaramuzzo
- Alessandro Pasculli
- Andrea Muratore
- Diego Visconti
- Francesca Cammelli
- Giuseppe Brisinda
- Francesco Salvetti
- Dario Iadicola
- Francesca D’Agostino
- Federica Chimenti
- Daunia Verdi
- Alessio Mazzoni
- Mauro Santarelli
- Fabio Benedetti
- Giovanni Bellanova
- Monica Zese
- Sonia Agrusti
- Beatrice Torre
- Carlo Mazzucchelli
- Davide Luppi
- Risso Alessandra
- Filippo Paratore
- Nicola Cillara
- Mario Herda
- Luisa Moretti
- Maximilian Scheiterle
- Pierpaolo Di Lascio
- Rossella Facchin
- Vincenzo Pappalardo
- Giovanni Pirozzolo
- Francesco Corradi
- Savino Occhionorelli
- Caterina Rizzo
- Stefano Piero Bernardo Cioffi
- Silvia Strambi
- Serena Musetti
- Valentina Murzi
- Franco Badile
- Fausto Rosa
- Francesca Sbuelz
- Rachele Monetti
- Angelo Baggiani
- Pietro Fransvea
- Rocco Scalzone
- Alice Salamone
- Leonardo Andrea Delogu
- Dario Parini
- Giuseppe Zocco
- Ismail Cengeli
Institutions
- University of Pisa (IT)
- Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda (IT)
- Ospedale “M. Bufalini” di Cesena (IT)
- Azienda Ospedaliera Universitaria Pisana (IT)
- University of Macerata (IT)
- University of Bari Aldo Moro (IT)
- University of Milano-Bicocca (IT)
Publication Details
- Journal
- Journal of Anesthesia Analgesia and Critical Care
- Published
- 2026-01-20
- DOI
- https://doi.org/10.1186/s44158-026-00338-2
- Primary Topic
- Sepsis Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00