Added value of quantitative [18F]FDG-PET analysis in MRI-negative epilepsy: A simulation-based study using realistic ground-truths
Quantitative analysis significantly improved diagnostic accuracy, confidence and inter-rater agreement, especially in challenging cases. Furthermore, this work introduces a novel methodological approach using simulated MRI-negative epilepsy [<sup>18</sup>F]FDG-PET images for realistic quantification research studies.
Authors
- Andrés Perissinotti (ORCID: https://orcid.org/0000-0003-4190-2425)
- Katherine Quintero (ORCID: https://orcid.org/0000-0002-5642-3905)
- Alberto Miceli (ORCID: https://orcid.org/0000-0001-6751-2412)
- Andrea Fritsch
- Jesús Silva‐Rodríguez (ORCID: https://orcid.org/0000-0002-5196-0103)
- María del Carmen Mallón-Araujo
- Julia Tamara Álvarez Cortés
- Arnau Farré-Melero
- Pablo Aguiar
- Aida Niñerola-Baizán
- Xavier Setoain
- Angela Esteban
- Silvia Morbelli
Institutions
- Azienda Ospedaliera Citta' della Salute e della Scienza di Torino (IT)
- Complejo Hospitalario Universitario de Santiago (ES)
- Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine (ES)
- Department of Medical Sciences (RU)
- Center for Research in Molecular Medicine and Chronic Diseases (ES)
- Hospital Clínic de Barcelona (ES)
- Ospedale Policlinico San Martino (IT)
- Instituto de Investigación Sanitaria de Santiago (ES)
- Fundacion Centro De Investigacion De Enfermedades Neurologicas (ES)
- Azienda Ospedaliera Nazionale SS. Antonio e Biagio e Cesare Arrigo (IT)
- University of Turin (IT)
- Universitat de Barcelona (ES)
Publication Details
- Journal
- NeuroImage
- Published
- 2026-01-20
- DOI
- https://doi.org/10.1016/j.neuroimage.2026.121740
- Primary Topic
- Epilepsy research and treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00