Modeling and simulation of neocortical micro- and mesocircuitry (Part I, anatomy)
The function of the neocortex is fundamentally determined by its repeating microcircuit motif, but also by its rich, interregional connectivity. We present a data-driven computational model of the anatomy of non-barrel primary somatosensory cortex of juvenile rat, integrating whole-brain scale data while providing cellular and subcellular specificity. The model consists of 4.2 million morphologically detailed neurons, placed in a digital brain atlas. They are connected by 14.2 billion synapses, comprising local, mid-range and extrinsic connectivity. We delineated the limits of determining connectivity from neuron morphology and placement, finding that it reproduces targeting by Sst+ neurons, but requires additional specificity to reproduce targeting by PV+ and VIP+ interneurons. Globally, connectivity was characterized by local clusters tied together through hub neurons in layer 5, demonstrating how local and interegional connectivity are complicit, inseparable networks. The model is suitable for simulation-based studies, and the model is made openly available to the community.
Authors
- Fabien Delalondre
- Jānis Lazovskis (ORCID: https://orcid.org/0000-0002-3285-7522)
- Hugo Dictus
- Juan Luis Riquelme (ORCID: https://orcid.org/0000-0003-4604-7405)
- Huanxiang Lu (ORCID: https://orcid.org/0000-0003-3377-9359)
- Alexis Arnaudon (ORCID: https://orcid.org/0000-0001-9486-1458)
- Werner Van Geit (ORCID: https://orcid.org/0000-0002-2915-720X)
- Lida Kanari (ORCID: https://orcid.org/0000-0002-9539-5070)
- Daniela Egas Santander (ORCID: https://orcid.org/0000-0001-9838-7992)
- András Ecker
- Srikanth Ramaswamy (ORCID: https://orcid.org/0000-0001-6642-7136)
- Adrien Devresse (ORCID: https://orcid.org/0000-0003-0071-3265)
- Samuel Lapere (ORCID: https://orcid.org/0000-0002-4207-2622)
- James B. Isbister
- Vishal Sood (ORCID: https://orcid.org/0000-0002-2167-7710)
- Liesbeth Vanherpe (ORCID: https://orcid.org/0000-0002-1226-0526)
- Gianluca Ficarelli (ORCID: https://orcid.org/0000-0002-2366-4008)
- Sirio Bolaños‐Puchet (ORCID: https://orcid.org/0000-0003-4049-6488)
- Joni Herttuainen (ORCID: https://orcid.org/0000-0001-7301-2350)
- Jason P. Smith (ORCID: https://orcid.org/0000-0002-4209-1604)
- Nicolas Ninin
- Christoph Pokorny (ORCID: https://orcid.org/0000-0002-9771-2180)
- Pramod Kumbhar (ORCID: https://orcid.org/0000-0002-1756-801X)
- Mohit Srivastava (ORCID: https://orcid.org/0000-0002-4566-4279)
- Thomas Delemontex (ORCID: https://orcid.org/0000-0003-3218-5137)
- Benoît Coste (ORCID: https://orcid.org/0000-0003-4408-0412)
- Cyrille Favreau (ORCID: https://orcid.org/0000-0003-1381-1585)
- James King (ORCID: https://orcid.org/0000-0003-0906-8389)
- Fernando Pereira (ORCID: https://orcid.org/0000-0002-5659-9521)
- Mike Gevaert
- Levi Ran
- Judit Santilari Planas
- Armando Romani
- Daniel Keller
- Henry Markram
- Felix Schürmann
- Matthias Wolf
- Ying Shi
- Eilif B Muller
- Jean-Denis Courcol
- Alexander Dietz
- Michael W Reimann
Institutions
- University of Debrecen (HU)
- University of Aberdeen (GB)
- Riga Technical University (LV)
- École Polytechnique Fédérale de Lausanne (CH)
- Nottingham Trent University (GB)
- Newcastle University (GB)
Publication Details
- Journal
- eLife
- Published
- 2026-01-20
- DOI
- https://doi.org/10.7554/elife.99688.3
- Primary Topic
- Neural dynamics and brain function
- Type
- article
- Field-Weighted Citation Impact
- 0.00