SPRED2 suppresses the stemness of hepatocellular carcinoma through the p53/miR-506-3p/KLF4 pathway
The current study revealed a novel SPRED2/p53/miR-506-3p/KLF4 axis through which SPRED2 contributes to the suppression of HCC cell stemness and provides a potential new target to prevent HCC progression.
Authors
- Masayoshi Fujisawa (ORCID: https://orcid.org/0000-0003-4794-4837)
- Toshiaki Ohara (ORCID: https://orcid.org/0000-0003-1557-1589)
- Aye Moh-Moh-Aung
- Teizo Yoshimura
- Sachio Ito
- Tong Gao
- Akihiro Matsukawa
- Tianyi Wang
Institutions
- Okayama University (JP)
Publication Details
- Journal
- Cancer Biology and Medicine
- Published
- 2026-01-20
- DOI
- https://doi.org/10.20892/j.issn.2095-3941.2025.0247
- Primary Topic
- Fibroblast Growth Factor Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Japan Society for the Promotion of Science