Unusual Cytology Features of A <scp> <i>DICER1</i> </scp> ‐Mutated Thyroid Nodule: Raising Awareness of A Potential Diagnostic Pitfall During Fine Needle Aspiration

DICER1-mutated thyroid lesions can range from indolent to aggressive neoplasms. Infarction has been recently described as a histologic feature of DICER1-mutated thyroid nodules. In this case report, we presented a DICER1-mutated nodule which presented predominantly with debris in the fine needle aspiration (FNA) specimen and was confirmed on surgical resection to be a near total infarcted nodule. To the best of our knowledge, this is the first cytopathology report of a DICER1-mutated thyroid lesion presenting as an infarcted nodule. Awareness of the features described herein may help prevent both overdiagnosis and underdiagnosis in the evaluation of thyroid nodules via FNA.

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Journal
Cytopathology
Published
2026-01-20
DOI
https://doi.org/10.1111/cyt.70053
Primary Topic
Congenital Diaphragmatic Hernia Studies
Type
article
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article

Unusual Cytology Features of A DICER1 ‐Mutated Thyroid Nodule: Raising Awareness of A Potential Diagnostic Pitfall During Fine Needle Aspiration

S. Levent Yilmaz, Qian Wang, Eduardo V. Zambrano, Wenli Dai
Cytopathology
Congenital Diaphragmatic Hernia Studies
article

Unusual Cytology Features of A DICER1 ‐Mutated Thyroid Nodule: Raising Awareness of A Potential Diagnostic Pitfall During Fine Needle Aspiration

S. Levent Yilmaz, Qian Wang, Eduardo V. Zambrano, Wenli Dai
article en

Abstract

DICER1-mutated thyroid lesions can range from indolent to aggressive neoplasms. Infarction has been recently described as a histologic feature of DICER1-mutated thyroid nodules. In this case report, we presented a DICER1-mutated nodule which presented predominantly with debris in the fine needle aspiration (FNA) specimen and was confirmed on surgical resection to be a near total infarcted nodule. To the best of our knowledge, this is the first cytopathology report of a DICER1-mutated thyroid lesion presenting as an infarcted nodule. Awareness of the features described herein may help prevent both overdiagnosis and underdiagnosis in the evaluation of thyroid nodules via FNA.

Cytopathology
Creighton University (US), University of Arizona (US), University of Pittsburgh (US), Phoenix Children's Hospital (US), Children's Hospital of Pittsburgh (US), University of Pittsburgh Medical Center (US)
Openalex Percentile: Top 83%
Congenital Diaphragmatic Hernia Studies
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