Unusual Cytology Features of A <scp> <i>DICER1</i> </scp> ‐Mutated Thyroid Nodule: Raising Awareness of A Potential Diagnostic Pitfall During Fine Needle Aspiration
DICER1-mutated thyroid lesions can range from indolent to aggressive neoplasms. Infarction has been recently described as a histologic feature of DICER1-mutated thyroid nodules. In this case report, we presented a DICER1-mutated nodule which presented predominantly with debris in the fine needle aspiration (FNA) specimen and was confirmed on surgical resection to be a near total infarcted nodule. To the best of our knowledge, this is the first cytopathology report of a DICER1-mutated thyroid lesion presenting as an infarcted nodule. Awareness of the features described herein may help prevent both overdiagnosis and underdiagnosis in the evaluation of thyroid nodules via FNA.
Authors
- S. Levent Yilmaz (ORCID: https://orcid.org/0009-0006-6071-5085)
- Qian Wang
- Eduardo V. Zambrano
- Wenli Dai
Institutions
- Creighton University (US)
- University of Arizona (US)
- University of Pittsburgh (US)
- Phoenix Children's Hospital (US)
- Children's Hospital of Pittsburgh (US)
- University of Pittsburgh Medical Center (US)
Publication Details
- Journal
- Cytopathology
- Published
- 2026-01-20
- DOI
- https://doi.org/10.1111/cyt.70053
- Primary Topic
- Congenital Diaphragmatic Hernia Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00