Novel Aggressive Subtype of Multiple System Atrophy Identified by Unsupervised Machine Learning
The SN-OPC-synchronous subtype provides insights into α-synuclein propagation mechanisms, suggesting multiple initial seeding sites rather than unidirectional spread. This computational approach uncovered disease heterogeneity undetectable by conventional methods, potentially benefiting clinical trials through patient stratification. ANN NEUROL 2026;99:989-1000.
Authors
- Ryan J. Uitti (ORCID: https://orcid.org/0000-0001-8113-4710)
- William P. Cheshire (ORCID: https://orcid.org/0000-0002-6364-5362)
- Michael DeTure (ORCID: https://orcid.org/0000-0002-4363-1262)
- Daisuke Ono (ORCID: https://orcid.org/0000-0002-0238-7355)
- Alexandra I. Soto‐Beasley (ORCID: https://orcid.org/0000-0002-0153-1917)
- Satoshi Hirai
- Owen Ross
- Alexia R. Maier
- Zbigniew K. Wszolek
- Dennis W. Dickson
Institutions
- Jacksonville College (US)
- WinnMed (US)
- The Institute of Statistical Mathematics (JP)
- Mayo Clinic in Florida (US)
Publication Details
- Journal
- Annals of Neurology
- Published
- 2026-01-20
- DOI
- https://doi.org/10.1002/ana.78131
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00