Hypnotic doses of fazamorexant induced less impairment on balance and cognition than zolpidem in healthy younger and elderly individualse

Clinically hypnotic doses of fazamorexant induced less balance, judgement and memory impairment in healthy adults and elderly volunteers compared to the comprehensive suppression of zolpidem on the neurological system. These preliminary results suggest that fazamorexant is a potentially safer drug for insomnia. No age-related pharmacokinetic difference was identified with fazamorexant.

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Publication Details

Journal
British Journal of Clinical Pharmacology
Published
2026-01-19
DOI
https://doi.org/10.1002/bcp.70414
Primary Topic
Sleep and Wakefulness Research
Type
article
Field-Weighted Citation Impact
0.00
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article

Hypnotic doses of fazamorexant induced less impairment on balance and cognition than zolpidem in healthy younger and elderly individualse

Wang Ruwei, Chen Xia, Jin Lü, Huang Xingxing
British Journal of Clinical Pharmacology
Sleep and Wakefulness Research
article

Hypnotic doses of fazamorexant induced less impairment on balance and cognition than zolpidem in healthy younger and elderly individualse

Wang Ruwei, Chen Xia, Jin Lü, Huang Xingxing
article en

Abstract

Clinically hypnotic doses of fazamorexant induced less balance, judgement and memory impairment in healthy adults and elderly volunteers compared to the comprehensive suppression of zolpidem on the neurological system. These preliminary results suggest that fazamorexant is a potentially safer drug for insomnia. No age-related pharmacokinetic difference was identified with fazamorexant.

British Journal of Clinical Pharmacology
Beijing Tian Tan Hospital (CN), Yangtze River Pharmaceutical Group (China) (CN), Hangzhou DAC Biotech (China) (CN)
Good health and well-being
Openalex Percentile: Top 84%
Sleep and Wakefulness Research
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