Plan meta-objective for sub-micron quantitative phase imaging

Quantitative phase imaging (QPI) provides valuable objective insights for investigating transparent samples, yet miniaturizing QPI systems without compromising performance remains a critical challenge for applications requiring compactness and portability. Here, by introducing partially coherent illumination modulation, together with a plan meta-objective (PMO) design, we present a compact QPI system with sub-micron resolution. The PMO is a monolithically integrated doublet metalens with its dispersion enabling focal shifts at two wavelengths, obviating the need for mechanical translations during image acquisition for phase retrieval. The PMO is also optimized to correct for monochromatic aberrations, delivering an object-side field of view equivalent to ~90% of the lens aperture with minimal distortion and aberrations. The spatial coherence of the illumination is controlled to enhance imaging resolution. By co-designing illumination and imaging systems, we demonstrate QPI achieving a half-pitch lateral resolution of 488 nm with a phase accuracy of 0.06λ. Our approach enables high-quality QPI analysis of diverse phase objects, including unstained biospecimens, laying the foundation for the development of compact, stable, and practical QPI platforms.

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Publication Details

Journal
Light Science & Applications
Published
2026-01-20
DOI
https://doi.org/10.1038/s41377-025-02099-z
Primary Topic
Advanced X-ray Imaging Techniques
Type
article
Field-Weighted Citation Impact
0.00

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article

Plan meta-objective for sub-micron quantitative phase imaging

Jitao Ji, Zhizhang Wang, Wenjing Shen, Junxiao Zhou et al.
Light Science & Applications
Advanced X-ray Imaging Techniques
article

Plan meta-objective for sub-micron quantitative phase imaging

Jitao Ji, Zhizhang Wang, Wenjing Shen, Junxiao Zhou, Shining Zhu Shining Zhu, Jie Sun, Chunyu Huang, Jian Li, Chen Chen, Junyi Wang, Tao Li
article en

Abstract

Quantitative phase imaging (QPI) provides valuable objective insights for investigating transparent samples, yet miniaturizing QPI systems without compromising performance remains a critical challenge for applications requiring compactness and portability. Here, by introducing partially coherent illumination modulation, together with a plan meta-objective (PMO) design, we present a compact QPI system with sub-micron resolution. The PMO is a monolithically integrated doublet metalens with its dispersion enabling focal shifts at two wavelengths, obviating the need for mechanical translations during image acquisition for phase retrieval. The PMO is also optimized to correct for monochromatic aberrations, delivering an object-side field of view equivalent to ~90% of the lens aperture with minimal distortion and aberrations. The spatial coherence of the illumination is controlled to enhance imaging resolution. By co-designing illumination and imaging systems, we demonstrate QPI achieving a half-pitch lateral resolution of 488 nm with a phase accuracy of 0.06λ. Our approach enables high-quality QPI analysis of diverse phase objects, including unstained biospecimens, laying the foundation for the development of compact, stable, and practical QPI platforms.

Light Science & ApplicationsVol. 15(1)
Collaborative Innovation Center of Advanced Microstructures (CN)
National Natural Science Foundation of China, Nanjing University
Openalex Percentile: Top 83%
Advanced X-ray Imaging Techniques
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