Cellular-Scale Photoreceptor Remodeling After Macular Hole Surgery Examined by Adaptive Optics Optical Coherence Tomography

This study provides in vivo cellular-resolution evidence for stepwise outer retinal remodeling following MH surgery. Recovery of the photoreceptor segments occurred specifically beneath the reappearing photoreceptor nuclear signals, indicating localized reorganization rather than passive displacement. Transient HRBs diminished in parallel with structural recovery and may represent intermediate stages of retinal remodeling. In conjunction with photoreceptor integrity, HRBs could serve as dynamic indicators of outer retinal repair in vivo.