Parathyroid-independent hypercalcemia as initial presentation of renal sarcoidosis with granulomatous interstitial nephritis: a case report

This case underscores the diagnostic difficulty of renal sarcoidosis, particularly in hypercalcemic patients without renal biopsy. Early use of corticosteroids can improve renal function, but complications like nephrolithiasis may still occur, so continuous monitoring is still necessary. A high index of suspicion and timely biopsy are essential for diagnosis and optimal management.

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Publication Details

Journal
Frontiers in Endocrinology
Published
2026-01-20
DOI
https://doi.org/10.3389/fendo.2025.1748226
Primary Topic
Sarcoidosis and Beryllium Toxicity Research
Type
article
Field-Weighted Citation Impact
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article

Parathyroid-independent hypercalcemia as initial presentation of renal sarcoidosis with granulomatous interstitial nephritis: a case report

Jishi Liu, Liu Li, Xixi Qiao, Yan Liu et al.
Frontiers in Endocrinology
Sarcoidosis and Beryllium Toxicity Research
article

Parathyroid-independent hypercalcemia as initial presentation of renal sarcoidosis with granulomatous interstitial nephritis: a case report

Jishi Liu, Liu Li, Xixi Qiao, Yan Liu, Bin Yi
article en

Abstract

This case underscores the diagnostic difficulty of renal sarcoidosis, particularly in hypercalcemic patients without renal biopsy. Early use of corticosteroids can improve renal function, but complications like nephrolithiasis may still occur, so continuous monitoring is still necessary. A high index of suspicion and timely biopsy are essential for diagnosis and optimal management.

Frontiers in EndocrinologyVol. 16
Central South University (CN), Third Xiangya Hospital (CN)
Gender equality
Openalex Percentile: Top 84%
Sarcoidosis and Beryllium Toxicity Research
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