Interventions for metabolic bone disease of prematurity: A systematic review and meta-analysis

Nutritional prophylaxis conclusively reduces MBDP incidence, while mechanical interventions effectively improve bone mineralization. Although no studies directly evaluated combined approaches, the complementary mechanisms of nutritional and mechanical interventions suggest that optimal prevention may involve integrating both strategies. Critical gaps persist in orthopedic management, necessitating future research on fracture protocols and surgical interventions.

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Publication Details

Journal
Metabolism Open
Published
2026-01-20
DOI
https://doi.org/10.1016/j.metop.2026.100445
Primary Topic
Infant Nutrition and Health
Type
article
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article

Interventions for metabolic bone disease of prematurity: A systematic review and meta-analysis

Abdullah Alburaey, M Maghrabi, Yazan Jumah Alalwani, Ahmed Y. Azzam et al.
Metabolism Open
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Interventions for metabolic bone disease of prematurity: A systematic review and meta-analysis

Abdullah Alburaey, M Maghrabi, Yazan Jumah Alalwani, Ahmed Y. Azzam, Amal Saad Alomari, Khawlah Abdullah Almana, Reem Hameed Alshammari, Sofia Sharif Abualmeza, Sara Abdulrahman Alharbi, Ghadi Naif Alsharif, Kholoud Khalid Alshehri, Asma Mossa Soweedi, Mujood Ali Alatta
article en

Abstract

Nutritional prophylaxis conclusively reduces MBDP incidence, while mechanical interventions effectively improve bone mineralization. Although no studies directly evaluated combined approaches, the complementary mechanisms of nutritional and mechanical interventions suggest that optimal prevention may involve integrating both strategies. Critical gaps persist in orthopedic management, necessitating future research on fracture protocols and surgical interventions.

Metabolism OpenVol. 29
University of Suffolk (GB), Alfaisal University (SA), King Abdulaziz University (SA), Umm al-Qura University (SA), King Saud University (SA), Imam Abdulrahman Bin Faisal University (SA), King Khalid University (SA), Jazan University (SA)
Zero hunger
Openalex Percentile: Top 83%
Infant Nutrition and Health
DOIOpen Access PDFOpenAlex
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