Impact of margin to depth of invasion ratio on oncologic outcome in locally advanced oral cancer undergoing surgery and chemoradiotherapy
MDR is an independent prognostic marker in LAOSCC treated with surgery and adjuvant CCRT. A cutoff of 0.35 effectively stratifies survival risk, even among patients with adequate surgical margins. Incorporating MDR into postoperative assessment could refine risk stratification and guide individualized follow-up and adjuvant treatment planning.
Authors
- F FANG
- Wen‐Ling Tsai (ORCID: https://orcid.org/0000-0003-2525-1060)
- T. L. Huang
- Hui-Ching Chuang (ORCID: https://orcid.org/0000-0001-8704-7036)
- Chao-Hui Yang
- Y T Lin
- Tsai Mh
- Hui Lu
- Chih-Yen Chien
Institutions
- National Sun Yat-sen University (TW)
- Chang Gung University (TW)
- Kaohsiung Chang Gung Memorial Hospital (TW)
- Cheng Shiu University (TW)
Publication Details
- Journal
- Clinical and Experimental Otorhinolaryngology
- Published
- 2026-01-19
- DOI
- https://doi.org/10.21053/ceo.2025-00339
- Primary Topic
- Head and Neck Cancer Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00